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Who defines the codes for conduct for society? What exactly is the norm? This episode of Taboo introduces five people living with conditions beyond their control that make them outsiders. Lizzie's rare condition is neonatal progeroid syndrome. No matter what she eats, she cannot gain weight, causing her to look much older than her age. At 350 pounds, James is hiding under his plus-size clothing with an asymmetrical condition that makes his left side dramatically larger than his right.